1. of current HIV global distribution and occurrence analysing UNAIDS, GBD and WHO’s data to highlight HIV is still an emerging disease. Historical contextualisation of CRISPR/Cas9 system as editing tool against HIV-1.2. of how current knowledge of the virus genetics enabled application of CRISPR/Cas9 nuclease to HIV-1, what is its current development against HIV-1 and its importance.3. Presentation of detailed analysis of CRISPR/Cas9 gene editing targets based on studies related to the molecular mechanism of HIV-1 infection.4. of limitations/benefits of using CRISPR/Cas9 as a gene-editing therapy for HIV-1 and where science is taking it next.
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